Design and assembly of double-crossover linear arrays of micrometre length using rolling circle replication

Authors: Lubrich, Daniel; Bath, Jonathan; Turberfield, Andrew J.

Source: Nanotechnology, Volume 16, Number 9, September 2005 , pp. 1574-1577(4)

Publisher: Institute of Physics Publishing

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Abstract:

We demonstrate the use of rolling circle replication to template linear DNA arrays whose sizes bridge the gap between nanometre-scale self-assembly and top-down lithographic fabrication. Using rolling circle replication we have produced an oligonucleotide containing several hundred repeats of a short sequence motif. On this template we have constructed, by self-assembly, an array consisting of two parallel duplexes periodically linked by antiparallel Holliday junctions. We have observed arrays up to 10 µm in length by atomic force microscopy.

Document Type: Research article

DOI: 10.1088/0957-4484/16/9/028

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