Layering, bundling, and azimuthal orientations in dense phases of nucleosome core particles
Authors: Cherstvy, A G; Everaers, R
Source: Journal of Physics: Condensed Matter, Volume 18, Number 50, 20 December 2006 , pp. 11429-11442(14)
Publisher: IOP Publishing
Abstract:We propose an idea how the helical pattern of charges on the surface of DNA can affect electrostatic interactions of nucleosome core particles in their columnar and crystalline phases as well as in chromatin. For bilayers of nucleosomes, we suggest that mutual azimuthal orientations of neighbouring NCPs are quantized with the angle of ≈/4. We suggest that a similar mechanism of DNA-mediated inter-nucleosome interactions might stabilize new chromatin-like bundled columnar phases of nucleosomes which have not yet been observed.
Document Type: Research Article
Publication date: 2006-12-20