Immobilising of anti‐HPV18 and E. coli O157:H7 antibodies on magnetic silica‐coated Fe3O4 for early diagnosis of cervical cancer and diarrhoea
Source: International Journal of Nanotechnology, Volume 8, Numbers 3-5, 2011 , pp. 383-398(16)
Publisher: Inderscience Publishers
Abstract:This paper presents the synthesis and properties of magnetic silica‐coated Fe3O4 nanoparticles. Uncoated Fe3O4 nanoparticles with an average diameter of 9‐16 nm and saturation magnetisation of around 66 emu/g were first prepared by co‐precipitation method. After being coated by SiO2 using the sol‐gel method, the diameters of the coated particles ranged from 29 nm to 230 nm and their corresponding saturation magnetisation was reduced to 29 emu/g. The magnetic coated nanoparticles were attached to the monoclonal antibodies of HPV18 and E. coli O157:H7. The TG/DTA analyses indicated that antibodies were attached to the magnetic nanoparticles. The obtained results revealed that magnetic SiO2‐coated Fe3O4 nanoparticles can be a promising candidate for the diagnosis of cervical cancer at an early stage with high accuracy.
Document Type: Research Article
Affiliations: 1: Department of Novel and Nanostructure Materials, Ho Chi Minh City Institute of Physic, 01 Mac Dinh Chi Str., Distr. 1, Ho Chi Minh City, Vietnam. 2: Department of Chemistry, Ho Chi Minh City University of Pedagogy, 280 An Duong Vuong, 4th Ward, Ho Chi Minh City, Vietnam. 3: Soc Son High School, Hon Dat Distr., Kien Giang Province, Vietnam. 4: Nguyen Thi Minh Khai High School, 66 B Nguyen Thi Minh Khai, Soc Trang Province, Vietnam
Publication date: 2011-01-01