Authors: Shin, Jeong-hoon¹; Go, Young-jin¹; Jeong, Kyu-Shik¹; Park, Sang-Joon¹; Kwak, Dong-Mi¹; Kwon, Oh-Deog¹; Jee, Young-Heun²; Ryu, Si-Yoon³; Yang, Taekeun⁴; Kim, Yuseok⁴; Kim, Chun-Ho⁴; Kang, Chang-Mo⁴; Kim, Tae-Hwan⁵

Source: International Journal of Low Radiation, Volume 6, Number 3, 11 October 2009 , pp. 209-218(10)

Publisher: Inderscience Publishers

Abstract:

The present study was designed to determine the possible protective effects of Gingko biloba extract (EGb) against cellular damage induced by irradiation (IR) in human lymphocytes and C56BL/6 murine cells. Murine spleen cells were exposed to IR after pretreatment with either saline or EGb, and treatments were repeated immediately after IR. Then the mice were decapitated at either 6 h or 72 h after whole-body IR, where intraperitoneal injections of EGb or saline were repeated once daily. Human peripheral lymphocytes were observed for the determination of the frequencies of apoptotic cells. All samples were also examined microscopically and assayed for the frequencies of apoptotic cells. The frequencies of apoptotic cells in human peripheral lymphocytes increased significantly in the saline-treated IR groups, but decreased significantly in the EGb-treated IR groups. The sizes of the murine spleen in the saline-treated IR groups decreased significantly compared with those in EGb-treated IR groups. The data demonstrated that EGb, through its free-radical scavenging and antioxidant properties, attenuates IR-induced apoptosis in radiosensitive cells, suggesting that EGb may have a potential benefit in enhancing radioprotective effects.

Keywords: ENVIRONMENTAL JOURNALS; Environment and Sustainable Development; HEALTHCARE AND LEISURE JOURNALS; Healthcare and Medical Engineering; ENVIRONMENTAL JOURNALS; Nuclear Science and Technology

Document Type: Research article

DOI: http://dx.doi.org/10.1504/IJLR.2009.028889

Affiliations: 1: College of Veterinary Medicine, Kyungpook National University, Daegu City 702 701, Korea. 2: College of Veterinary Medicine, Jeju National University, Korea. 3: College of Veterinary Medicine, Chungnam National University, Korea. 4: Korea Institute of Radiological and Medical Sciences, 1370 Sanggyeok-Dong, Buk-ku, Taegu 702 701, Korea. 5: College of Veterinary Medicine, Kyungpook National University, Daegu City 702 701, Korea

Publication date: 2009-10-11

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• The International Journal of Low Radiation is a peer-reviewed journal dedicated to the publication of research articles, review papers and technical notes in all domains related to low-dose radiation, among which are the biological and health effects in humans and the biota, in vitro and in vivo research on low radiation effects, regulatory and policy aspects, risk estimation and public perception.
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• By this author: Shin, Jeong-hoon ;  Go, Young-jin ;  Jeong, Kyu-Shik ;  Park, Sang-Joon ;  Kwak, Dong-Mi ;  Kwon, Oh-Deog ;  Jee, Young-Heun ;  Ryu, Si-Yoon ;  Yang, Taekeun ;  Kim, Yuseok ;  Kim, Chun-Ho ;  Kang, Chang-Mo ;  Kim, Tae-Hwan

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