Author: Hayes, Daniel P.

Source: International Journal of Low Radiation, Volume 5, Number 4, 29 October 2008 , pp. 368-394(27)

Publisher: Inderscience Publishers

Abstract:

Our general understanding and appreciation of the multifaceted protective actions of vitamin D have recently entered a new era. It is now becoming recognised that its most active molecular form, 1,25-dihydroxyvitamin D<SUB align=right>3 (also known as calcitriol), may offer protection against a variety of radiation- and otherwise-induced damages. As will be discussed, vitamin D carries out its protective actions by a host of mechanisms, among these being cell cycle regulation and proliferation, cellular differentiation and communication, Programmed Cell Death (PCD) (apoptosis and autophagy) and antiangiogenesis. As will be proposed and developed, vitamin D, with its preventative&#47;ameliorating actions, should be considered among the prime (if not the primary) nonpharmacological agents that offer protection against sublethal low radiation damage and, in particular, against radiation-induced cancer.

Keywords: ENVIRONMENTAL JOURNALS; Environment and Sustainable Development; HEALTHCARE AND LEISURE JOURNALS; Healthcare and Medical Engineering; ENVIRONMENTAL JOURNALS; Nuclear Science and Technology

Document Type: Research article

DOI: http://dx.doi.org/10.1504/IJLR.2008.020980

Affiliations: 1: Office of Radiological Health, New York City Department of Health and Mental Hygiene, 2 Lafayette Street, New York, New York 10007, USA

Publication date: 2008-10-29

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• The International Journal of Low Radiation is a peer-reviewed journal dedicated to the publication of research articles, review papers and technical notes in all domains related to low-dose radiation, among which are the biological and health effects in humans and the biota, in vitro and in vivo research on low radiation effects, regulatory and policy aspects, risk estimation and public perception.
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