Adipose Tissue Expandability in the Maintenance of Metabolic Homeostasis

Authors: Gray, Sarah L.; Vidal-Puig, Antonio J.

Source: Nutrition Reviews, Volume 65, Supplement 1, June 2007 , pp. 7-12(6)

Publisher: International Life Sciences Institute

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Abstract:

Adipose tissue expands to accommodate increased lipid through hypertrophy of existing adipocytes and by initiating differentiation of preadipocytes. The capacity of adipose tissue to expand is critical for accommodating changes in energy availability, but this capacity is not an unlimited process and likely varies between individuals. We suggest that it is not the absolute amount of adipose tissue but rather the capacity of adipose tissue to expand that affects metabolic homeostasis. Here we highlight examples of disease states and transgenic animal models with altered adipose tissue function that support this hypothesis and discuss possible mechanisms by which altered adipose tissue expandability impairs metabolic homeostasis.

Keywords: ADIPOKINES; ADIPOSE TISSUE; EXPANDABILITY; LIPOTOXICITY; METABOLIC HOMEOSTASIS

Document Type: Research article

DOI: http://dx.doi.org/10.1301/nr.2007.jun.S7-S12

Publication date: 2007-06-01

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