Visceral Adipocytes and the Metabolic Syndrome

Author: Tchernof, André

Source: Nutrition Reviews, Volume 65, Supplement 1, June 2007 , pp. 24-29(6)

Publisher: International Life Sciences Institute

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Abstract:

Recently, the high responsiveness of omental adipocytes to positive lipolytic stimuli has been clearly demonstrated in women. We conclude that adipose tissue fatty acid release, storage capacity, and secreted cytokines may all be involved in the etiology of the metabolic syndrome. The anatomical location of visceral adipocytes close to the liver, combined with possible depot-specific alterations in various adipocyte or adipose tissue features likely play critical roles in this process. This highly complex etiology is concordant with the heterogeneous clinical manifestations of the metabolic syndrome, and suggests possible interindividual variability in the extent to which each pathophysiological mechanism is involved.

Keywords: ADIPOSE TISSUE; CARDIOMETABOLIC RISK FACTORS; OMENTAL; SUBCUTANEOUS

Document Type: Research article

DOI: http://dx.doi.org/10.1301/nr.2007.jun.S24-S29

Publication date: 2007-06-01

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