Leucine and Protein Synthesis: mTOR and Beyond

Author: Stipanuk, Martha H.

Source: Nutrition Reviews, Volume 65, Number 3, March 2007 , pp. 122-129(8)

Publisher: International Life Sciences Institute

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Abstract:

The effects of amino acid intake on protein synthesis in the intact rat appear to be mediated almost entirely by a single amino acid: leucine. The effect of leucine on protein synthesis appears to be closely associated with eIF4G phosphorylation and its association with eIF4E, but whether eIF4G phosphorylation actually mediates the effects of leucine or is merely associated with these events has not been elucidated. Additional research is needed to determine whether leucine effects eIF4G phosphorylation, whether eIF4G phosphorylation is essential for the effect of leucine on protein synthesis, and whether mTOR (mammalian target of rapamycin) or another component of the mTOR complex is somehow involved in leucine-specific signaling.

Keywords: AMINO ACIDS; INSULIN; LEUCINE; MTOR; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN SYNTHESIS

Document Type: Review article

DOI: http://dx.doi.org/10.1301/nr.2007.mar.122-129

Publication date: 2007-03-01

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