Chromium Picolinate Intake and Risk of Type 2 Diabetes: An Evidence-Based Review by the United States Food and Drug Administration

Authors: Trumbo, Paula R.; Ellwood, Kathleen C.

Source: Nutrition Reviews, Volume 64, Number 8, August 2006 , pp. 357-363(7)

Publisher: International Life Sciences Institute

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Abstract:

The labeling of both health claims that meet significant scientific agreement (SSA) and qualified health claims on conventional foods and dietary supplements requires pre-market approval by the US Food and Drug Administration (FDA). Approval by the FDA involves, in part, a thorough review of the scientific evidence to support an SSA or a qualified health claim. This article discusses FDA's evidence-based review of the scientific evidence on the role of chromium picolinate supplements in reducing the risk of type 2 diabetes. Based on this evidence-based review, FDA issued a letter of enforcement discretion for one qualified health claim on chromium picolinate and risk of insulin resistance, a surrogate endpoint for type 2 diabetes. The agency concluded that the relationship between chromium picolinate intake and insulin resistance is highly uncertain.

Keywords: CHROMIUM PICOLINATE; DIABETES; HEALTH CLAIMS; TYPE 2 DIABETES

Document Type: Research article

DOI: http://dx.doi.org/10.1301/nr.2006.aug.357-363

Publication date: 2006-08-01

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