Is the Small Intestine a Gluconeogenic Organ?

Author: Watford, Malcolm

Source: Nutrition Reviews, Volume 63, Number 10, October 2005 , pp. 356-360(5)

Publisher: International Life Sciences Institute

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Abstract:

Gluconeogenesis is responsible for the maintenance of blood glucose levels as hepatic glycogen stores become depleted. Traditionally, only liver and kidney have been believed to be capable of gluconeogenesis, but a gluconeogenic capacity for the small intestine has recently been proposed. This possibility is supported by the expression of key gluconeogenic enzymes and radiolabeled tracer experiments, but these data are not unequivocal and alternative roles can explain the presence of gluconeogenic enzymes in this organ.

Document Type: Review article

DOI: http://dx.doi.org/10.1301/nr.2005.oct.356-360

Publication date: 2005-10-01

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