Biological Role of Vitamin C in Keratinocytes

Authors: Catani, Maria Valeria; Savini, Isabella; Rossi, Antonello; Melino, Gerry; Avigliano, Luciana

Source: Nutrition Reviews, Volume 63, Number 3, March 2005 , pp. 81-90(10)

Publisher: International Life Sciences Institute

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Abstract:

Epidemiological studies have suggested an association between vitamin C (and other antioxidant vitamins) and cancer risk. However, the mechanisms accounting for prevention have not been extensively investigated. In skin, vitamin C (ascorbic acid) exerts different biological roles, including photoprotective effects and participation in collagen synthesis. This paper reports new findings about additional functions of the vitamin. Vitamin C counteracts oxidative stress via transcriptional and post-translational mechanisms; this modulation may interfere with the activity of redox-sensitive transcription factors, commitment to differentiation or cell cycle arrest, and apoptosis in response to DNA damage. All of these vitamin C-mediated responses might be important in different cell types, allowing for the maintenance of body homeostasis.

Keywords: KERATINOCYTES; VITAMIN C; ASCORBIC ACID AP-1; NF-KB; OXIDATIVE STRESS

Document Type: Research article

DOI: http://dx.doi.org/10.1301/nr.2005.mar.000-000

Publication date: 2005-03-01

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