Using Genetic Admixture to Study the Biology of Obesity Traits and to Map Genes in Admixed Populations

Authors: José R. Fernández; Mark D. Shiver

Source: Nutrition Reviews, Supplement 1 , pp. 69-74(6)

Publisher: International Life Sciences Institute

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Abstract:

Differences among ethnic and racial groups in obesity-related traits have been clearly established in the scientific literature. To explore the genetic component underlying these differences, the genetic admixture approach has been used. In this approach, ancestry informative genetic markers are used to estimate a quantitative value representing the degree of ancestral background in individuals of admixed genetic background. Genetic admixture has been successfully used to explain racial and ethnic variation in obesity related traits; however, the understanding and measure of cultural and environmental components that also influence these phenotypes still requires further exploration.

Keywords: RACIAL/ETHNIC DIFFERENCES; ANCESTRY INFORMATIVE MARKERS; GENETIC ADMIXTURE; OBESITY

Document Type: Research article

DOI: http://dx.doi.org/10.1301/nr.2004.jul.S69-S74

Affiliations: 1: Division of Physiology and Metabolism, Department and Nutrition Sciences; Section on Statistical Genetics, Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama at Birmingham, 1530 3rd Ave S, Birmingham, AL 352

Publication date: 2004-07-01

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