Modulation of Monocyte-Macrophage Function with -Tocopherol: Implications for Atherosclerosis

Authors: Devaraj S.; Harris A.; Jialal I.

Source: Nutrition Reviews, Volume 60, Number 1, 1 January 2002 , pp. 8-14(7)

Publisher: International Life Sciences Institute

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Abstract:

Cardiovascular disease is the leading cause of morbidity and mortality in the Western world. Monocyte-macrophages are crucial cells in atherogenesis. Several lines of evidence suggest that antioxidants, especially -tocopherol, have beneficial effects with regard to cardiovascular disease. -Tocopherol has beneficial effects on cell functions that are pivotal in atherogenesis. -Tocopherol inhibits platelet aggregation and proinflammatory activity of monocytes. In vitro data also support an effect of -tocopherol on smooth muscle cell proliferation and endothelial function. Finally, recent data support an effect of -tocopherol on macrophage function. The mounting evidence from in vitro and in vivo studies provides a sound scientific basis for -tocopherol supplementation. Further clinical trials are required, however, before a definitive recommendation can be made for primary and secondary prevention of heart disease.

Keywords: CARDIOVASCULAR DISEASE; ANTIOXIDANTS; PLATELET AGGREGATION; ALPHA-TOCOPHEROL

Document Type: Research article

Publication date: 2002-01-01

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