Distribution and Residue Depletion of Oxytetracycline in Giant Freshwater Prawn (Macrobrachium rosenbergii)

Authors: Poapolathep, Amnart¹; Poapolathep, Saranya²; Imsilp, Kanjana²; Wannapat, Nutthapong³; Klangkaew, Narumol²; Kusutjarit, Napasorn²; Kumagai, Susumu⁴

Source: Journal of Food Protection®, Volume 71, Number 4, April 2008 , pp. 870-873(4)

Publisher: International Association for Food Protection

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Abstract:

Distribution and residue depletion patterns of oxytetracycline were examined in giant freshwater prawns, Macrobrachium rosenbergii, after medicated-feed treatment at the feeding level of 4 g/kg of feed for 5 consecutive days. The concentration of oxytetracycline in prawn muscle tissues was measured using high-performance liquid chromatography equipped with a fluorescence detector. The limit of detection was 0.1 μg/g. In the medicated-feed-treated group, oxytetracycline was detectable 8 days posttreatment at the feeding level of 4 g/kg of feed for 5 consecutive days. The depletion half-life and mean residence time of oxytetracycline were 30.96 and 100.3 h, respectively. The dose of 4 g/kg of feed for 5 consecutive days can be recommended for therapeutic dosage regimen in giant freshwater prawn aquaculture. The minimal withdrawal period of M. rosenbergii muscle tissue should be 8 days postcessation of medicated feed.

Document Type: Research article

Affiliations: 1: Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900 Thailand; Department of Veterinary Public Health, Graduate School of Agricultural and Life Science, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Toky 2: Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900 Thailand 3: Chaiyaphum Inland Fisheries Station, Chaiyaphum 36130 Thailand 4: Department of Veterinary Public Health, Graduate School of Agricultural and Life Science, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 1138657, Japan

Publication date: 2008-04-01

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Distribution and Residue Depletion of Oxytetracycline in Giant Freshwater Prawn (Macrobrachium rosenbergii)

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