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Antimicrobial Activity of Native Chitosan, Degraded Chitosan, and O-Carboxymethylated Chitosan

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The antimicrobial activity of native chitosan was compared to that of lipase-degraded chitosan. The effects of O-carboxymethylated (O-CM) substitution on native (molecular weight, 120; degree of deacetylation, 84.71%) and lipase-degraded chitosans were also investigated. The antimicrobial activity of native chitosan was more extensive than that of lipase-degraded chitosan; however, lipase-degraded chitosan was still highly effective and more water-soluble. O-CM chitosan derived from degraded chitosan was more effective than O-CM chitosan derived from native chitosan. O-CM substitution enhanced lipasedegraded chitosan's antimicrobial activity without reducing its solubility.


Document Type: Miscellaneous

Affiliations: 1: Department of Packaging Science, Clemson University, Clemson, South Carolina, 29634-0370, USA 2: Department of Food Science and Technology, Chung-Ang University, Ansung, Korea 3: Department of Packaging Science, Clemson University, Clemson, South Carolina, 29634-0370, USA & Graduate School of Biotechnology, Korea University, Seoul 136-701, Korea

Publication date: August 1, 2003

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