Toxicity of Moniliformin from Fusarium fujikuroi Culture Material to Growing Barrows
Abstract:In two studies, the effects of moniliformin (M)-contaminated diets from Fusarium fujikuroi culture material on growing barrows were evaluated. In the first study, six barrows (three replicates of two each, mean body weight = 17.8 kg) per group (four groups; 24 barrows total) were fed diets calculated to contain 0 mg M/kg feed (control); 25 mg M/kg feed; 50 mg M/ kg feed; or 100 mg M/kg feed for 28 days. In the second study, the same experimental design and numbers of barrows (mean body weight = 15.3 kg) were used, and diets were formulated to contain 0 mg M/kg feed (control); 50 mg M/kg feed; 100 mg M/kg feed; or 200 mg M/kg feed. Diets of 100 mg or 200 mg M/kg feed reduced body weight, body weight gain, and feed consumption. Serum biochemical analytes were affected by 100 to 200 mg M/kg feed. Hematologic values were affected by 50, 100, and 200 mg M/kg feed. In the first study, one barrow in the 100 mg M-treated group died, and in the second study, one barrow died in the 100 mg M-treated group, and five barrows died in the 200 mg M-treated group. Relative heart weight was increased in the 200 mg M-treated barrows, yet tissues from organs collected from treatment groups were generally histologically unimpressive. The most consistent sign of M toxicity in barrows appeared to be death induced within 2 to 5 days by 100 to 200 mg M/kg feed.
Document Type: Research Article
Affiliations: 1: Food and Feed Safety Research Unit, Agricultural Research Service, U.S. Department of Agriculture, 2881 F&B Road, College Station, Texas 77845, USA 2: Food and Feed Safety Research Unit, Agricultural Research Service, U.S. Department of Agriculture, 2881 F&B Road, College Station, Texas 77845, USA 3: Veterinary Medical Diagnostic Laboratory, University of Missouri, Columbia, Missouri 65211, USA
Publication date: November 1, 2001
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