Antimicrobial Properties of Human Lysozyme Transgenic Mouse Milk
Abstract:The antimicrobial properties of standard human lysozyme and the milk of transgenic mice expressing human lysozyme were investigated using bacterial strains important to the dairy industry. Standard human lysozyme was found to be effective at significantly slowing the growth of the milk cold-spoilage organism Pseudomonas fragi (P < 0.001). of a clinical isolate of the mastitis-causing organism Staphylococcus aureus (P < 0.005), and of a nonpathogenic strain of E. coli (P < 0.05). Milk from transgenic mice secreting human lysozyme in their milk at an average concentration of 0.38 mg/ml was found to be bacteriostatic against the cold-spoilage organisms Pseudomonas fragi and Lactobacillus viscous and a mastitis-causing strain of Staphylococcus aureus, but not against a pathogenic strain of E. coli. These results demonstrate that transgenic animals producing human lysozyme in their milk can affect the microbial nature of milk.
Document Type: Research Article
Affiliations: 1: Department of Animal Science, School of Veterinary Medicine, University of California—Davis, Davis, California 95616, USA 2: Department of Population Health and Reproduction, School of Veterinary Medicine, University of California—Davis, Davis, California 95616, USA 3: Department of Animal Science, School of Veterinary Medicine, University of California—Davis, Davis, California 95616, USA; Department of Population Health and Reproduction, School of Veterinary Medicine, University of California—Davis, Davis, California 95616, USA
Publication date: January 1, 1998
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