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Antimicrobial Activity of 2-Pyrrolidone-5-Carboxylic Acid Produced by Lactic Acid Bacteria

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Thirteen Lactobacillus and five Pediococcus strains were shown to produce an antimicrobial agent, 2-pyrrolidone-5-carboxylic acid (PCA). PCA inhibited many spoilage bacteria, particularly Enterobacter cloacae 1575, Pseudomonas fluorescens KJL G, and P. putida 1560-2. The antimicrobial activity of PCA did not change at higher temperatures. However, the activity was destroyed rapidly by neutralization with ammonium hydroxide. PCA showed slightly lower antimicrobial activity than lactic acid.


Document Type: Research Article

Affiliations: 1: Department of Food Technology, FIN-00014, University of Helsinki, Valio Ltd., Helsinki 00101, Finland 2: Research and Development Center, Valio Ltd., Helsinki 00101, Finland

Publication date: July 1, 1997

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