Anti-Invasive Activity of Bovine Lactoferrin against Listeria monocytogenes
Source: Journal of Food Protection®, Number 3, March 1997, pp. 215-331 , pp. 267-271(5)
Abstract:We have investigated the possible role of bovine lactoferrin in protecting the intestinal epithelium from bacterial infections, using as an in vitro model enterocyte-like cell lines HT-39 and Caco-2 infected with a food-borne pathogen, Listeria monocytogenes. When infection occurred in the presence of 1 mg/ml of bovine lactoferrin, in the form of apolactoferrin or iron- or manganese-saturated forms, the adhesion of bacteria to eukaryotic cells was unaffected, but the number of internalized bacteria was reduced by 42- to 125-fold. The possibility of a toxic effect of lactoferrin was excluded, because bovine lactoferrin was used at nonbactericidal and noncytotoxic concentrations.
Document Type: Research Article
Affiliations: 1: Department of Pure and Applied Biology, University of L'Aquila, Coppito, 67010 L'Aquila, Italy 2: Institute of Microbiology, Faculty of Medicine, II University of Naples, 80138 Napoli, Italy 3: Institute of Microbiology, Faculty of Medicine, 11 University of Naples, 80138 Napoli, Italy 4: Institute of Microbiology, Faculty of Medicine, University of Rome La Sapienza, 00185 Roma, Italy 5: Institute of Microbiology, Faculty of Medicine, II University of Naples, 80138 Napoli
Publication date: March 1, 1997
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