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Production of the Mycotoxin Cyclopiazonic Acid by Penicillium commune on Solid Agar Media: Effects of Water Activity, Temperature, and Incubation Time

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The combined effects of water activity (aw), temperature, incubation time, and medium composition on cyclopiazonic acid (CPA) production by an isolate of Penicillium commune was studied using a full-factorial experimental design. An analysis of variance for the mycotoxin showed that there was a complex interaction between all these factors and that this affected the production of CPA. The minimum aw for CPA production (0.025 to 0.238 μg ml−1) in yeast extract agar was 0.90 whereas in Czapek yeast autolysate agar it was 0.85 (0.048 to 0.123 μg ml−1). The temperature range for CPA production was 20 to 30°C. The optimum temperature for CPA production was 25°C. CPA was maximally produced (3.199 to 3.993 μg ml−1) at an aw of 0.996 after 15 days of incubation.


Document Type: Research Article

Affiliations: 1: Department of Bioscience and Biotechnology, University of Strathclyde, 204 George Street, Glasgow G1 1XW, UK 2: Institute of Arable Crops Research—Rothamsted, Harpenden, Herts, AL5 2JQ, UK 3: Department of Statistics and Modeling Science, University of Strathclyde, 26 Richmond Street, Glasgow G1 1XH, UK

Publication date: August 1, 1996

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