Primary T-cell lymphoma of the thyroid: case report and review of the literature
Authors: Yang, Hongbo1; Li, Jian2; Shen, Ti3
Source: Medical Oncology, Volume 25, Number 4, December 2008 , pp. 462-466(5)
Publisher: Humana Press
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- In this Subject: Oncology
- By this author: Yang, Hongbo ; Li, Jian ; Shen, Ti
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Abstract:
Here we report a rare case of primary T-cell lymphoma of the thyroid gland. A 32-year-old Chinese man was admitted to our hospital because of marked goiter and subcutaneous nodules. Computed tomography (CT) scan of the neck disclosed diffuse enlargement of the thyroid gland. A diagnosis of peripheral T-cell lymphoma was made according to cytopathological findings of fine-needle aspiration (FNA) of the thyroid gland and skin biopsy. Immunohistochemistry stain showed that the tumor was positive for CD3 and negative for CD20. Clonal T-cell receptor (TCR-γ) gene rearrangements were demonstrated by polymerase chain reaction. After six cycles of combination chemotherapy (bleomycin, cyclophosphamide, doxorubicin, vincristine, and prednisone), the thyroid retracted to normal size gradually.Keywords: Thyroid lymphoma; T-cell
Document Type: Research article
DOI: 10.1007/s12032-008-9059-x
Affiliations: 1: Department of Endocrinology and Metabolism, Peking Union Medical College Hospital, Shuai Fu Yuan 1#, DongCheng District, Beijing, 100730, P.R. China, 2: Department of Hematology, Peking Union Medical College Hospital, Shuai Fu Yuan 1#, DongCheng District, Beijing, 100730, P.R. China, Email: leej93@yahoo.com.cn 3: Department of Hematology, Peking Union Medical College Hospital, Shuai Fu Yuan 1#, DongCheng District, Beijing, 100730, P.R. China,
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