Primary T-cell lymphoma of the thyroid: case report and review of the literature

Authors: Yang, Hongbo¹; Li, Jian²; Shen, Ti³

Source: Medical Oncology, Volume 25, Number 4, December 2008 , pp. 462-466(5)

Buy & download fulltext article:

Price: $42.00 plus tax (Refund Policy)

Abstract:

Here we report a rare case of primary T-cell lymphoma of the thyroid gland. A 32-year-old Chinese man was admitted to our hospital because of marked goiter and subcutaneous nodules. Computed tomography (CT) scan of the neck disclosed diffuse enlargement of the thyroid gland. A diagnosis of peripheral T-cell lymphoma was made according to cytopathological findings of fine-needle aspiration (FNA) of the thyroid gland and skin biopsy. Immunohistochemistry stain showed that the tumor was positive for CD3 and negative for CD20. Clonal T-cell receptor (TCR-γ) gene rearrangements were demonstrated by polymerase chain reaction. After six cycles of combination chemotherapy (bleomycin, cyclophosphamide, doxorubicin, vincristine, and prednisone), the thyroid retracted to normal size gradually.

Keywords: Thyroid lymphoma; T-cell

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s12032-008-9059-x

Affiliations: 1: Department of Endocrinology and Metabolism, Peking Union Medical College Hospital, Shuai Fu Yuan 1#, DongCheng District, Beijing, 100730, P.R. China, 2: Department of Hematology, Peking Union Medical College Hospital, Shuai Fu Yuan 1#, DongCheng District, Beijing, 100730, P.R. China, Email: leej93@yahoo.com.cn 3: Department of Hematology, Peking Union Medical College Hospital, Shuai Fu Yuan 1#, DongCheng District, Beijing, 100730, P.R. China,

Publication date: 2008-12-01