Microangiopathic hemolysis refractory to plasmapheresis responding to docetaxel and cisplatin: A case report

Authors: Marcoullis, George¹; Abebe, Lool²; Jain, Dharamvir³; Talusan, Richard³; Bhagwati, Niyati³; Wiernik, Peter³

Source: Medical Oncology, Volume 19, Number 3, September 2002 , pp. 189-192(4)

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Abstract:

We report the case of a 56-yr-old woman with adenocarcinoma of unknown origin metastatic to the bone marrow presenting with a thrombotic thrombocytopenic purpura-like syndrome refractory to protracted daily plasmapheresis and steroids but readily and completely responsive to docetaxel plus cisplatin. Sustained and complete response was pathologically confirmed.

Keywords: Adenocarcinoma of unknown origin; thrombotic thrombocytopenic purpura; taxanes; cisplatin; plasma exchange; protein-A immunoadsorption; alkylating agents

Document Type: Research article

DOI: http://dx.doi.org/10.1385/MO:19:3:189

Affiliations: 1: Comprehensive Cancer Center Our Lady of Mercy Medical Center, New York Medical College, Bronx, NY, Email: gmarcoullis@olmhs.org 2: Department of Pathology, Our Lady of Mercy Medical Center, New York Medical College, Bronx, NY, 3: Comprehensive Cancer Center Our Lady of Mercy Medical Center, New York Medical College, Bronx, NY,

Publication date: 2002-09-01