Running to stand still: Ionotropic receptor dynamics at central and peripheral synapses

Authors: Bruneau, Emile¹; Akaaboune, Mohammed²

Source: Molecular Neurobiology, Volume 34, Number 2, October 2006 , pp. 137-151(15)

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Abstract:

For synapses to form and function, neurotransmitter receptors must be recruited to a location on the postsynaptic cell in direct apposition to presynaptic neurotransmitter release. However, once receptors are inserted into the postsynaptic membrane, they are not fixed in place but are continually exchanged between synaptic and extrasynaptic regions, and they cycle between the surface and intracellular compartments. This article highlights and compares the current knowledge about the dynamics of acetylcholine receptors at the vertebrate peripheral neuromuscular junction and AMPA, N-methyl-d-aspartate, and γ-aminobutyric acid receptors in central synapses.

Keywords: Acetylcholine receptor; AMPA receptor; NMDA receptor; GABA receptor; neuromuscular junction; cycling; dynamics; recycling; turnover; half-life

Document Type: Research article

DOI: http://dx.doi.org/10.1385/MN:34:2:137

Affiliations: 1: Department of Molecular, Cellular and Developmental Biology and Program in Neuroscience, University of Michigan, Ann Arbor, MI, 2: Department of Molecular, Cellular and Developmental Biology and Program in Neuroscience, University of Michigan, Ann Arbor, MI, Email: makaabou@umich.edu

Publication date: 2006-10-01