Pharmacological study of the novel compound FLZ against experimental parkinson's models and its active mechanism

Authors: Feng, WeiHong¹; Wei, HuaiLing¹; Liu, Geng²

Source: Molecular Neurobiology, Volume 31, Numbers 1-3, February 2005 , pp. 295-300(6)

Buy & download fulltext article:

Price: $42.00 plus tax (Refund Policy)

Abstract:

FLZ is a synthetic new derivative of squamosamide. Pharmacological study found that FLZ given orally improved the abnormal behavior caused by the functional disturbance of dopaminergic and cholinergic neurons in mice. FLZ significantly increased the content of dopamine and its metabolites in striatum in MPTP model mice. FLZ also remarkably protected dopaminergic PC-12 cells against dopamine and MPP⁺ induced injury and apoptosis in vitro. The compound inhibited the formation of dopamine-melanin and protein polymers. Additionally, FLZ inhibited cytochrome-c release from mitochondria and caspase-3 activation by dopamine in PC-12 cells. The above results suggest that compound FLZ possesses anti-PD activity through neuroprotection.

Keywords: Parkinson's disease; dopaminergic neurons; oxidative stress; apoptosis; compound FLZ; MPTP; dopamine

Document Type: Research article

DOI: http://dx.doi.org/10.1385/MN:31:1-3:295

Affiliations: 1: Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, China, 2: Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, China, Email: gtliu2002@yahoo.com

Publication date: 2005-02-01