Complement Components and Their Autoantibodies

Authors: P. Norsworthy; K. A. Davies

Source: Molecular Biotechnology, Volume 23, Number 3, May 2003 , pp. 259-270(12)

Publisher: Humana Press

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Abstract:

The purpose of the immune system is to defend the host from constantly changing microbial pathogens. Autoimmune diseases develop as a consequence of the production of antibodies and/or cells that react with self-antigens, and may recruit other effector mechanisms that result in tissue damage. Thus, in this context, autoimmunity represents an immune response to self-antigens that is sufficient to cause disease. This article is specifically devoted to autoantibodies directed against complement components.

Keywords: Autoantibodies; complement components; autoimmunity

Document Type: Miscellaneous

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