Involvement of Membrane-Associated Proteins in the Acute Regulation of Cellular Fatty Acid Uptake

Authors: Glatz J.F.C.; Luiken J.J.F.P.; Bonen A.

Source: Journal of Molecular Neuroscience, Volume 16, Numbers 2-3, July 2001 , pp. 123-132(10)

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Abstract:

The transport of long-chain fatty acids across cellular membranes most likely occurs to some extent by passive diffusion and additionally is facilitated by a number of membrane-associated and cytoplasmic proteins. In this overview we focus on the involvement of the membrane proteins fatty acid translocase (FAT/CD36), plasma membrane fatty acid-binding protein (FAB Ppm) and fatty acid-transport protein (FATP). Newly obtained evidence is presented that in skeletal muscle, fatty acid uptake is subject to short-term regulation by translocation of FAT/CD36 from intracellular stores to the plasma membrane, analogous to the regulation of muscular glucose uptake by GLUT-4 translocation. These new findings establish a significant role of membrane-associated proteins in the cellular fatty acid-uptake process. Possible implications for the uptake and transport of long-chain fatty acids by the brain are discussed.

Keywords: Long-chain fatty acids; fatty acid-binding protein; lipid binding protein; fatty acid translo-case; fatty acid-transport protein; CD36; giant vesicles

Language: English

Document Type: Research article

Publication date: 2001-07-01