Mucosal T cell response to reovirus

Authors: Chen, Daohong¹; Rubin, Donald²

Source: Immunologic Research, Volume 23, Numbers 2-3, June 2001 , pp. 229-234(6)

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Abstract:

During the last three decades, immunologists and gastroenterologists have witnessed the formation of mucosal immunology as a discipline in biomedical science, and studies of reovirus infection have substantially contributed to this evolution. We have focused on mucosal T cell responses induced by reovirus in conventional, germfree, nude, and NF-κB deficient mice. Several major facets of T cell function in the immune responses to this mucosal pathogen have been examined, including viral selection of oligoclonal-T cells, extrathymic T cell development, and distinct signaling pathways used by CD8 sublineages. In addition, our findings with virus-specific T cells selected in the mucosa have suggested novel mechanisms for the rearrangement, selection, and expansion of TCR genes. With the increasing application of molecular tools, reovirus will continue to be a useful model pathogen to study mucosal immunology and will further our understanding of mucosal immunity in health and disease.

Keywords: Mucosal Immunity; Reovirus; T Cells; NF-κB; Thymus-Independent; Cytotoxic T Cells

Document Type: Research article

DOI: http://dx.doi.org/10.1385/IR:23:2-3:229

Affiliations: 1: Departments of Research Medicine, VA TVHCS, Medicine, Microbiology and Immunology, Vanderbilt University, 1310 24th Avenue S, 37212, Nashville, TN, 2: Departments of Research Medicine, VA TVHCS, Medicine, Microbiology and Immunology, Vanderbilt University, 1310 24th Avenue S, 37212, Nashville, TN, Email: don.h.rubin@vanderbilt.edu

Publication date: 2001-06-01