Authors: Kar, Dilip¹; Agarwal, Gaurav¹; Mehta, Bhavna²; Agarwal, Jyotsna³; Gupta, Ramesh²; Dhole, Tapan³; Mishra, Saroj⁴

Source: Endocrine Pathology, Volume 12, Number 3, September 2001 , pp. 355-359(5)

Publisher: Humana Press

Abstract:

A 36-year-old female presented with generalized bone pain, muscular weakness, and enlarged cervical lymph nodes. The biochemical findings and skeletal survey were suggestive of primary hyperparathyroidism (PHPT). CT of neck and thorax showed enlarged multiple lymph nodes in the cervical and superior mediastinal region. With a diagnosis of PHPT, she underwent cervical exploration and excision of enlarged right inferior parathyroid gland, along with biopsy of nodes. Histopathology revealed the features of parathyroid adenoma with a few foci of epithelioid granuloma and granulomatous lymphoadenitis. Smear and culture were negative for AFB. A positive PCR for Mycobacterium tuberculosis of the homogenates of parathyroid tumor confirmed tuberculous inflammation within the parathyroid adenoma. To the best of our knowledge, this is the first reported case of parathyroid adenoma associated with tuberculous pathology in a case of PHPT.

Keywords: Tuberculosis; granulomatous inflammation; tuberculos granuloma; primary hyperparathyroidism; parathyroid adenoma

Document Type: Research article

DOI: http://dx.doi.org/10.1385/EP:12:3:355

Affiliations: 1: Department of Endocrine Surgery, SGPGIMS, Raebareli Road, 226014, Lucknow, India, 2: The Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, 226 014, Lucknow, India, 3: The Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, 226 014, Lucknow, India, 4: Department of Endocrine Surgery, SGPGIMS, Raebareli Road, 226014, Lucknow, India, Email: skmishra@sgpgi.ac.in

Publication date: 2001-09-01

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