@article {Pestereli:September 2001:1046-3976:301,
	author = "Pestereli, Hadice",
	author = "Ogus, Mehmet",
	author = "Oren, Nural",
	author = "Karpuzoglu, Gulten",
	author = "Karpuzoglu, Tuncer",
	title = "Bcl-2 and p53 expression in insular and in well-differentiated thyroid carcinomas with an insular pattern",
	journal = "Endocrine Pathology",
	volume = "12",
	year = "September 2001",
	abstract = "Expression of p53 and bcl-2 oncogenes was investigated in poorly differentiated, so-called insular carcinomas of the thyroid gland and also in the follicular and papillary carcinomas with an insular component. Hematoxylin-eosin sections of 217 thyroid carcinomas were reevaluated for insular carcinoma and also for thyroid carcinomas with an insular component. Immunohistochemical staining method was used for detecting p53 and bcl-2 expression on paraffin blocks of three pure insular, five follicular or papillary thyroid carcinomas with a major insular component (more than 50%) and six with a minor insular component (20-50%). Flow cytometry was also performed in these cases. None of the cases showed p53 immunoreactivity. Bcl-2 expression was observed in all cases and the most intense staining was seen in insular areas. All the cases were diploid. We suggest that bcl-2 plays a role in loss of differentiation of thyroid carcinomas.",
	pages = "301-305(5)",
	url = "http://www.ingentaconnect.com/content/hum/ep/2001/00000012/00000003/art00006"
	doi = "doi:10.1385/EP:12:3:301"
}