Bcl-2 and p53 expression in insular and in well-differentiated thyroid carcinomas with an insular pattern

Authors: Peştereli, Hadice¹; Öğüş, Mehmet²; Ören, Nural¹; Karpuzoğlu, Gülten¹; Karpuzoğlu, Tuncer²

Source: Endocrine Pathology, Volume 12, Number 3, September 2001 , pp. 301-305(5)

Publisher: Humana Press

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Abstract:

Expression of p53 and bcl-2 oncogenes was investigated in poorly differentiated, so-called insular carcinomas of the thyroid gland and also in the follicular and papillary carcinomas with an insular component. Hematoxylin-eosin sections of 217 thyroid carcinomas were reevaluated for insular carcinoma and also for thyroid carcinomas with an insular component. Immunohistochemical staining method was used for detecting p53 and bcl-2 expression on paraffin blocks of three pure insular, five follicular or papillary thyroid carcinomas with a major insular component (more than 50%) and six with a minor insular component (20-50%). Flow cytometry was also performed in these cases. None of the cases showed p53 immunoreactivity. Bcl-2 expression was observed in all cases and the most intense staining was seen in insular areas. All the cases were diploid. We suggest that bcl-2 plays a role in loss of differentiation of thyroid carcinomas.

Keywords: Insular thyroid carcinoma; p53; bcl-2; DNA content

Document Type: Research article

DOI: 10.1385/EP:12:3:301

Affiliations: 1: Department of Pathology, Akdeniz University, Türkiye, 2: Department of Surgery, Akdeniz University, Türkiye,

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