Authors: Ding, Yanfeng¹; Zou, Ruijiao¹; Judd, Robert¹; Zhong, Juming²

Source: Endocrine, Volume 29, Number 1, February 2006 , pp. 135-141(7)

Publisher: Humana Press

Abstract:

The main characteristics of type 1 diabetic cardiomyopathy include depressed contractility and altered electrophysiological properties in ventricular myocytes. The goal of the present study was to determine the potential influence of gender in the diabetes-induced pathogenesis of ventricular myocyte function. Diabetes in both male and female rats was induced by a single intravenous injection of streptozotocin (STZ). Diabetic rats exhibited hyperglycemia and reduced body weight gain in both male and female groups. Neither contractile profiles nor activity of three types of K⁺ channels of ventricular myocytes was significantly different between nondiabetic male and female rats. Ventricular myocytes isolated from diabetic rats exhibited significant depresion in cell contraction and relaxation, which was associated with depression of intracellular Ca²⁺ ([Ca²⁺]_i) transient. The degrees of contractile depression were comparable in ventricular myocytes obtained from both male and female diabetic rats. Similarly, diabetes depressed three types of outward K⁺ currents (Ito, Ik, and iss) to the same extent in both gender myocytes. These data demonstrate that in this animal model of diabetes, gender difference in cardiac myocyte functions was eliminated.

Keywords: Diabetes; gender; cardiac myocyte; cell shortening; Ca2+ transient; potassium channels

Document Type: Research article

DOI: http://dx.doi.org/10.1385/ENDO:30:2:237

Affiliations: 1: Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, 36849, Auburn, Alabama, 2: Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, 36849, Auburn, Alabama, Email: zhongju@auburn.edu

Publication date: 2006-02-01

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