Authors: Kumar, Arvind¹; Teuber, Suzanne¹; Naguwa, Stanley¹; Prindiville, Thomas²; Gershwin, M.³

Source: Clinical Reviews in Allergy and Immunology, Volume 30, Number 1, February 2006 , pp. 61-70(10)

Publisher: Humana Press

Abstract:

The immunological basis of eosinophilic gastroenteritis (EGE) is an interesting contrast between the enigma of urticaria and the increasing usage of molecular technology in clinical allergy. Little is known about the natural history of EGE. It has been known to spontaneously remit, but the typical course, especially in adults, is one of chronic and intermittent disease. Given the often chronic nature of this disease, it is important to use relatively benign treatments initially and limit the use of systemic corticosteroids. Also, given the fact that eosinophilic infiltration of the gastrointestinal tract may also be a manifestation of other potentially dangerous disease processes, such as malignancy or hypereosinophilic syndrome, which may be initially diagnosed as EGE, routine surveillance of the cardiopulmonary and gastrointestinal systems is important. We present a patient who demonstrates the variability of presentation and treatment response in this multifaceted disease. The fact that he has apparently entered remission also makes his an uncommon presentation of EGE.

Keywords: Eosinophilia; abdominal pain; grapefruit-induced urticaria

Document Type: Research article

DOI: http://dx.doi.org/10.1385/CRIAI:30:1:061

Affiliations: 1: Division of Rheumatology, Allergy, and Clinical Immunology, Department of Internal Medicine, School of Medicine, University of California, Davis, Davis, CA, 2: Division of Gastroenterology, Department of Internal Medicine, School of Medicine, University of California, Davis, Davis, CA, 3: Division of Rheumatology, Allergy, and Clinical Immunology, Department of Internal Medicine, School of Medicine, University of California, Davis, Davis, CA, Email: megershwin@ucdavis.edu

Publication date: 2006-02-01

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