Cardiac valvulopathy in the antiphospholipid syndrome

Authors: Lev, Shaul¹; Shoenfeld, Yehuda²

Source: Clinical Reviews in Allergy and Immunology, Volume 23, Number 3, December 2002 , pp. 341-348(8)

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Abstract:

The Libman and Sacks non bacterial endocarditis was reported in 1924 in patients with SLE. Its relation to the anti cardiolpin syndrome has only been described as recently as the last decade. In this paper we review the deposition of theses antibodies on the valve with complement components initiating the deformation of the valve. The valvulopathy in APS is quite common and may lead to valve replacement. In addition, a diversity of manifestations are detailed. More awareness should be drawn to this new complication of APS.

Keywords: Antiphospholipid syndrome; systemic lupus erythromatosus; anti cardiolipin; antiphospholipid antibodies; heart valves; Libman-Sacks endocarditis; valvulopathy; mitral valve

Document Type: Research article

DOI: http://dx.doi.org/10.1385/CRIAI:23:3:341

Affiliations: 1: Department of Internal Medicine “B” Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, 52621, Tel-Hashomer, Israel, 2: Department of Internal Medicine “B” Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, 52621, Tel-Hashomer, Israel, Email: Shoenfel@post.tau.ac

Publication date: 2002-12-01