The Na,K-ATPase receptor complex: Ist Organization and Membership

Authors: Pierre, Sandrine¹; Xie, Zijian²

Source: Cell Biochemistry and Biophysics, Volume 46, Number 3, October 2006 , pp. 303-315(13)

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Abstract:

A major difference between the Na,K-ATPase ion pump and other P-type ATPases is its ability to bind cardiotonic steroids such as ouabain. Na,K-ATPase also interacts with many membrane and cytosolic proteins. In addition to their role in Na,K-ATPase regulation, it became apparent that some of the newly identified interactions are capable of organizing the Na,K-ATPase into various signaling complexes. This new function confers a ligand-like effect to cardiotonic steroids on cellular signal transduction. This article reviews these new developments and provides a comparison of Na,K-ATPase-mediated signal transduction with other receptors and ion transporters.

Keywords: Cardiotonic steroids; isoforms; c-Src; lipid kinase; caveolae; calcium

Document Type: Research article

DOI: http://dx.doi.org/10.1385/CBB:46:3:303

Affiliations: 1: Department Physiology, Pharmacology, Metabolism and Cardiovascular Sciences, Medical University of Ohio, 43614, Toledo, OH, 2: Department Physiology, Pharmacology, Metabolism and Cardiovascular Sciences, Medical University of Ohio, 43614, Toledo, OH, Email: zxie@meduohio.edu

Publication date: 2006-10-01