Protein translocation across the peroxisomal membrane

Authors: Azevedo, Jorge¹; Costa-Rodrigues, João²; Guimarães, Carla²; Oliveira, Márcia²; Sá-Miranda, Clara²

Source: Cell Biochemistry and Biophysics, Volume 41, Number 3, October 2004 , pp. 451-468(18)

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Abstract:

Peroxisomal matrix proteins are synthesized on free cytosolic ribosomes and posttranslationally imported into the organelle. Translocation of these newly synthesized proteins across the peroxisomal membrane requires the concerted action of many different proteins, the majority of which were already identified. However, not much is known regarding the mechanism, of protein translocation across this membrane system. Here, we discuss recent mechanistic and structural data. These results point to a model in which proteins en route to the peroxisomal matrix are translocated across the organelle membrane by their own receptor in a process that occurs, through a large membrane protein assembly.

Keywords: Peroxisome; protein targeting; protein translocation; membrane; peroxin; biogenesis

Document Type: Research article

DOI: http://dx.doi.org/10.1385/CBB:41:3:451

Affiliations: 1: Instituto de Biologia Molecular e Celular, Rua do Campo Alegre, 823, 4150-180, Porto, Portgal, Email: jazevedo@ibmc.up.pt 2: Instituto de Biologia Molecular e Celular, Rua do Campo Alegre, 823, 4150-180, Porto, Portgal,

Publication date: 2004-10-01