Inflammation-induced “Channelopathies” in the gastrointestinal smooth muscle

Authors: Malykhina, Anna¹; Akbarali, Hamid²

Source: Cell Biochemistry and Biophysics, Volume 41, Number 2, October 2004 , pp. 319-330(12)

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Abstract:

Inflammation markedly alters the motility patterns of the gastrointestinal tract, resulting mostly in decreased excitability of smooth muscle. There is emerging evidence indicating that inflammation alters ion channel expression and function of smooth muscle cells. In this review we summarize studies defining the mechanisms affecting contractile and electrical activity of gastrointestinal smooth muscle. We have focused on the evidence for decreased calcium channel conductance and alterations in the intracellular signaling mechanisms and discuss the role of muscarinic receptor activation in models of gastrointestinal inflammation. We propose that some of the clinical symptoms of altered smooth muscle contraction in pathogenesis of gut disorders such as inflammatory bowel disease may be regulated at the level of the ion channel.

Keywords: Gastrointestinal smooth muscle; contraction; ion channels; Src kinase; muscarinic receptors

Document Type: Research article

DOI: http://dx.doi.org/10.1385/CBB:41:2:319

Affiliations: 1: Department of Physiology, University of Oklahoma, Health Sciences Center, 73104, Oklahoma City, OK, 2: Department of Physiology, University of Oklahoma, Health Sciences Center, 73104, Oklahoma City, OK, Email: hamid-akbarali@ouhsc.edu

Publication date: 2004-10-01