Authors: Ayhanci, Adnan¹; Uyar, Ruhi²; Aral, Erinc³; Kabadere, Selda²; Appak, Sila⁴

Source: Biological Trace Element Research, Volume 126, Numbers 1-3, December 2008 , pp. 186-193(8)

Publisher: Humana Press

Abstract:

Cyclophosphamide (CP) is widely used for the treatment of neoplastic diseases; however, its toxicity causes dose-limiting side effects. Zinc (Zn) is an essential trace element and has important biological functions that control many cell processes including DNA synthesis, normal growth, reproduction, fetal development, bone formation, and wound healing. Therefore, the toxicity of CP and the possible protective effect of Zn on blood cells, bone marrow, and bladder of rat were investigated in this study. Intraperitoneal administration of 50, 100, or 150 mg/kg CP for 3 days caused, in a dose-dependent manner, reductions in the number of leukocytes, thrombocytes, and bone marrow nucleated cells and a serious urotoxicity. To explore whether CP-induced damages could be prevented by Zn, other groups of rats were pretreated with 4 or 8 mg/kg ZnCl₂ intraperitoneally for 3 days then challenged with respective doses of CP plus ZnCl₂ on day 4 for three more days. The results indicated that treatment of rats with Zn could dose-dependently alleviate CP-induced toxicities on blood cells, bone marrow cells, and urinary bladder. We suggest that Zn could be a potentially effective drug in the prevention of CP-related hematoxicity and urotoxicity.

Keywords: Zinc; Cyclophosphamide; Hematopoietic system; Bladder; Rat

Document Type: Research article

DOI: http://dx.doi.org/10.1007/s12011-008-8189-5

Affiliations: 1: Department of Biology, Faculty of Medicine, Faculty of Art and Sciences, Eskisehir Osmangazi University, Eskisehir, Turkey, Email: aayhanci@ogu.edu.tr 2: Department of Physiology, Faculty of Art and Sciences, Eskisehir Osmangazi University, Eskisehir, Turkey, 3: Department of Histology, Faculty of Art and Sciences, Eskisehir Osmangazi University, Eskisehir, Turkey, 4: Department of Molecular Biology and Genetics, Faculty of Science, Izmir Institute of Technology, 35430, a, Izmir, Turkey, Email: silaappak@iyte.edu.tr

Publication date: 2008-12-01

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