Selected zinc metabolism parameters in relation to insulin, renin-angiotensin-aldosterone system, and blood pressure in healthy subjects: Gender Differences

Author: Tubek, Slawomir

Source: Biological Trace Element Research, Volume 114, Numbers 1-3, December 2006 , pp. 65-72(8)

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Abstract:

The relationship between the renin-angiotensin-aldosterone system and insulin concentration and selected zinc (Zn) metabolism parameters and arterial blood pressure in young healthy subjects of both sexes is presented in this study. The following parameters were measured: systolic and diastolic arterial blood pressure, total and ouabain-dependent efflux rate constants of Zn from lymphocytes, serum and lymphocyte Zn concentrations, serum aldosterone, angiotensin-converting enzyme, insulin, sodium and potassium concentrations, body mass index, and plasma rennin activity. The correlations among these parameters show gender-dependent differences, except for a negative correlation between serum Zn and ouabain-dependent Zn efflux rate constant and the serum level of angiotensin-converting enzyme, and a positive relationship between the total efflux rate constant of Zn from lymphocytes and the serum aldosterone levels, both of which were gender independent. The results led us to conclude that there is a gender-independent functional relation between Zn homeostasis and the renin-angiotensin-aldosterone system. Insulin does not appear to play a significant role in Zn homeostasis.

Keywords: Zinc; zinc efflux from lymphocytes; insulin; renin plasma activity; angiotensin-converting enzyme; aldosterone; blood pressure; sex differences

Document Type: Research article

DOI: http://dx.doi.org/10.1385/BTER:114:1:65

Affiliations: 1: Faculty of Physical Education and Physiotherapy, Institute of Technology, Opole, Poland, Email: slawomir.tubek@hipokrates.org

Publication date: 2006-12-01