Authors: Massadeh, Adnan M.; Al-Safi, Saafan

Source: Biological Trace Element Research, Volume 108, Numbers 1-3, December 2005 , pp. 279-286(8)

Publisher: Humana Press

Abstract:

Chronic exposure (3.5 mo) of mice to cadmium (Cd), lead (Pb), or a cadmium–lead mixture at a concentration of 1 ppm in drinking water induced a highly significant inhibition of antibody response to human serum. The highest immunosuppression (84.4%) was induced by the Cd-Pb mixture, whereas Cd caused the lowest immunosuppression (53.6%). The body burden of Cd and Pb in various organs was investigated in the four groups of mice by atomic absorption spectrometry. The highest level of Cd was found in the kidney of the Cd-treated group, and the highest level of Pb was found in the liver of the Pb- and Cd-Pb–treated groups. It is concluded that when mice are exposed concurrently to Cd and Pb, they develop synergistic immunsuppression. Analysis of Cd levels using atomic absorption spectrometry revealed that it was distributed in the following order: kidney > liver > spleen > heart, whereas Pb was distributed in the following order: liver > kidney > spleen > heart.

Keywords: Analysis; cadmium; lead; atomic absorption spectrometry; immunosuppression

Document Type: Miscellaneous

Publication date: 2005-12-01

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