Lactic acid fermentation in cell-recycle membrane bioreactor

Authors: Choudhury, B.¹; Swaminathan, T.²

Source: Applied Biochemistry and Biotechnology, Volume 128, Number 2, February 2006 , pp. 171-183(13)

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Abstract:

Traditional lactic acid fermentation suffers from low productivity and low product purity. Cell-recycle fermentation has become one of the methods to obtain high cell density, which results in higher productivity. Lactic acid fermentation was investigated in a cell-recycle membrane bioreactor at higher substrate concentrations of 100 and 120 g/dm³. A maximum cell density of 145 g/dm³ and a maximum productivity of 34 g/(dm³…h) were achieved in cell-recycle fermentation. In spite of complete consumption of substrate, there was a continuous increase in cell density in cell-recycle fermentation. Control of cell density in cell-recycle fermentation was attempted by cell bleeding and reduction in yeast extract concentration.

Keywords: Lactic acid fermentation; cell-recycle reactor; membrane bioreactor; cell bleeding; continuous fermentation; high cell density

Document Type: Research article

DOI: http://dx.doi.org/10.1385/ABAB:128:2:171

Affiliations: 1: Department of Chemical Engineering, Indian Institute of Technology, 600 036, Madras, Chennai, India, 2: Department of Chemical Engineering, Indian Institute of Technology, 600 036, Madras, Chennai, India, Email: tswami@iitm.ac.in

Publication date: 2006-02-01