IngentaConnect Surface modification of neural probes with conducting polymer pol...

Authors: Xiao, Yinghong¹; Martin, David²; Cui, Xinyan³; Shenai, Mahesh⁴

Source: Applied Biochemistry and Biotechnology, Volume 128, Number 2, February 2006 , pp. 117-129(13)

Abstract:

A novel conducting polymer, poly(hydroxymethylated-3,4-ethylenedioxy-thiophene) (PEDOT-MeOH), was electrochemically deposited onto the electrodes of micromachined neural probes. Uniformly distributed film was obtained from aqueous solution when doped with polystyrenesulfonate. The surface morphology was rough and had good cellular adhesion. Impedance spectroscopy showed that the magnitude of coated electrode was lower than that of the bare gold over a range of frequencies from 10⁰ to 10⁵ Hz. Since the biocompatibility of the interface between the neural probes and brain tissue plays an important role when the probes are implanted in the central nervous system for long-term application, biomolecules were incorporated into the coating. Nonapeptide CDPGYIGSR was codeposited as the counterion in the conducting films. The surface morphology of the coating was fuzzy, providing many bioactive sites for interaction with neural cells. The magnitude of impedance was as low as 53 kω at the biologically relevant frequency of 1 kHz. An in vitro experiment demonstrated that the neuroblastoma cells grew preferentially on the PEDOT-MeOH/CDPGYIGSR-coated electrode sites and spread beyond the electrode area.

Keywords: Conducting polymer; surface modification; micromachined neural probe; biocompatibility

Document Type: Research article

DOI: 10.1385/ABAB:128:2:117

Affiliations: 1: School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, China, Email: xiaonust@tom.com 2: Department of Materials Science and Engineering, The University of Michigan, Ann Arbor, MI, 3: Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 4: Center for Biologic Nanotechnology, The University of Michigan, Ann Arbor, MI,

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Surface modification of neural probes with conducting polymer poly(hydroxymethylated-3,4-ethylenedioxythiophene) and its biocompatibility