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Open Access Influence of tamarind seed gum derivatives on the in vitro performance of gastro-retentive tablets based on hydroxypropylmethylcellulose

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The in vitro performance of gastro-retentive tablets containing metformin was investigated comprising work of adhesion (W), swelling and drug release. To measure W a method was adapted to apply shear stress horizontally. Tablets based on hydroxypropylmethylcellulose (HPMC) were compared with those containing a fraction of tamarind seed gum (TSG) or its derivatives instead of HPMC. Surprisingly, the TSG as well the derivatives investigated here were lowering W but they were increasing drug release rate and swelling of the tablets. TSG of carboxyl methyl type increased both dissolution and swelling significantly whilst W remained unchanged.

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Document Type: Short Communication

Publication date: 2012-11-01

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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