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Open Access An application of high performance liquid chromatographic assay for the kinetic analysis of degradation of faropenem

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An isocratic RP-HPLC-DAD procedure was developed and validated for kinetic analysis of degradation of faropenem in bulk drug substance and in tablets. It involved the use of a C-18 analytical column (5 μm particle size, 250 mm × 4.6 mm), flow rate 1.3 ml/min and 50 μl injection volume. The mobile phase consisted of acetate buffer (pH 3.5) – acetonitrile (70:30 v/v). The determination was carried out at the wavelength of 323 nm. Kinetic studies of faropenem degradation in aqueous solutions included hydrolysis, oxidation, photolysis and thermal degradation. A derivative spectrophotometry was used as an alternative method to compare the observed rate constants.

Document Type: Research Article

DOI: http://dx.doi.org/10.1691/ph.2012.2016

Publication date: November 1, 2012

More about this publication?
  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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