Authors: Nishimori, H.¹; Kondoh, M.²; Isoda, K.¹; Tsunoda, S.³; Tsutsumi, Y.^{4, 3}; Yagi, K.¹

Source: Die Pharmazie - An International Journal of Pharmaceutical Sciences, Volume 64, Number 6, 1 June 2009 , pp. 395-397(3)

Publisher: Govi-Verlag

Abstract:

In the pharmaceutical industry, nano-size materials are designed as drug carriers and diagnosis probes. Interactions between nano-size materials and chemicals need investigating. Here, we investigated whether nano-size materials affect chemical-induced toxicity using silica particles, which have been widely used in cosmetics and drug delivery and have diameters of 70 (SP70), 300 (SP300) and 1000 (SP1000) nm, a popular anti-tumor agent, cisplatin, and a widely used herbicide, paraquat. Mice were treated with either cisplatin (100 μmol/kg, intraperitoneally) or paraquat (50 mg/kg, intraperitoneally), with or without intravenous silica particle administration. All treatments were non-lethal and did not show severe toxicity, except for injection with both cisplatin and SP70, which were lethal. When mice received with paraquat and/or the silica particles, synergistic enhanced toxicity was observed in both paraquat- and SP70-treated mice. These synergic effects were not observed with either Si300 or 1000 treatment. Our findings suggest that further evaluation on the interaction between nano-size materials and chemicals is critical for the pharmaceutical application of nanotechnology.

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Document Type: Research article

DOI: http://dx.doi.org/10.1691/ph.2009.9048

Affiliations: 1: Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan 2: Laboratory of Bio-Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, 565-0871, Japan, Email: masuo@phs.osaka-u.ac.jp 3: Laboratory of Pharmaceutical Proteomics, Division of Biomedical Research, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan 4: Laboratory of Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan

Publication date: 2009-06-01

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• Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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