Skip to main content

Open Access Release of anti-inflammatory drugs from a silicone elastomer matrix system

Download Article:
 Download
(PDF 202.3 kb)
 

Abstract:

The focus of the current study was to overcome the obstacles to incorporating non-steroidal anti-inflammatory drugs (NSAIDs) into a medical silicone elastomer and to investigate how the physicochemical properties of the drugs affect the curing process and drug release. Five representative NSAIDs were selected with different molecular weights and physicochemical properties. Silicone blends with 1% (w/w) drug in the sodium salt form could be obtained in a fully cured medical elastomer matrix whereas drugs in various other salt forms or the free acid form interfered with the curing process. The release rate was mainly dependent on the solubility in the drug-salt elastomer matrix, with ibuprofen sodium showing the fastest rate. These results indicate that inclusion of the NSAID salts in the silicone matrix does not change the microstructure or the permeability of the silicone matrix, and channel formation is minimal. The properties of NSAID-containing silicone blends are compatible with processes used for the manufacture of medical devices from silicone such as silicone stents or catheters, and could therefore be considered for such devices to reduce inflammation at the site of an implant and also for local delivery.

Document Type: Research Article

DOI: http://dx.doi.org/10.1691/ph.2008.8206

Affiliations: 1: Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland 2: Össur hf., Reykjavik, Iceland 3: Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, Reykjavik, IS-107, Iceland, Iceland, Email: mmasson@hi.is

Publication date: January 1, 2009

More about this publication?
  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
govi/pharmaz/2009/00000064/00000001/art00004
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more