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Open Access In vitro breast cancer cell lethality of Brazilian plant extracts

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Abstract:

In this study we screened the cytotoxicity of 1220 plant extracts obtained from 351 plants belonging to 74 families occurring in the Amazon and Atlantic rain forests against MCF-7 human breast adenocarcinoma cell lines. All extracts were tested at a dose of 100 μg/mL. Only 11 aqueous or organic extracts belonging to the Annonaceae, Apocynaceae, Araceae, Clusiaceae, Flacourtiaceae, Leguminosae, Olacaceae and Violaceae showed marked lethal activity. Vismia guianensis and Annona hypoglauca extracts showed the greatest lethal activity.

Document Type: Research Article

DOI: https://doi.org/10.1691/ph.2007.10.6767

Affiliations: 1: Laboratório de Extração, Universidade Paulista, Av. Paulista, 900 1° andar, São Paulo, 01310-100, Brazil, Email: extractlab@unip.br 2: Laboratório de Extração, Universidade Paulista, São Paulo, Brazil

Publication date: 2007-10-01

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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