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Open Access Pharmacokinetics and urinary excretion of eprosartan in Chinese healthy volunteers of different gender

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The study aims to evaluate the pharmacokinetics and urinary excretion of eprosartan in Chinese healthy volunteers and to study the effect of gender on pharmacokinetics of eprosartan. Twenty healthy volunteers (ten men and ten women) were recruited for an open trial and received a single dose of 600 mg eprosartan. Using a validated LC/MS/MS method, plasma and urinary concentrations of eprosartan were defermined. The following pharmacokinetic parameters were elucidated after administration: the area under the plasma concentration versus time curve from 0 to 32 h (AUC0–32 h) 14818.75 ± 7312.11 ng · h/mL, the area under the plasma concentration versus time curve from 0 to infinite (AUC0–∞) 15081.62 ± 7379.63 ng · h/mL, peak plasma concentration (Cmax) 3664.25 ± 1653.94 ng · h/mL, time to Cmax (Tmax) 1.63 ± 0.46 h, elimination half-life (t1/2) 8.03 ± 4.04 h, apparent clearance (CL/F) 47.84 ± 19.21 L/h, apparent volume of distribution of the central compartment (V/F) 537.21 ± 287.91 L, renal clearance (CLr) 1.33 ± 0.41 L/h, amount of unchanged eprosartan excreted into urine 18.44 ± 6.43 mg and fraction of unchanged eprosartan excreted into urine 3.07 ± 1.07 %. Our results also indicated that no gender differences were observed in the pharmacokinetics of eprosartan in Chinese healthy volunteers.
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Document Type: Research Article

Affiliations: 1: Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, 180 Fen Lin Road, Shanghai, 200032, P.R. China, Email: [email protected] 2: Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, P.R. China 3: Shanghai Xu Hui District Central Hospital, Shanghai, P.R. China

Publication date: 2007-10-01

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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