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Open Access Development of an analytical method for the evaluation of N,N-dimethylformamide in dosage form design

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N,N-Dimethylformamide (DMF) is a well-known chemical entity that is extensively used for pharmaceutical, biomedical and chemical applications. Previous research identified the need for the development of an effective dosage form for the systemic delivery of DMF due to its unique antiviral properties. For purposes of quality control and evaluation during pharmaceutical product development, development of an analytical method was required. A gas chromatographic (GC) method was developed with a flame-ionization detector (FID) on a carbowax packed glass column. 2-Methoxyethanol was used as internal standard. The analytical method proved to be capable of separating DMF and 2-methoxyethanol adequately within a relatively short runtime of 2.5 min. The analytical method described was primarily developed for use in dissolution studies of DMF containing delivery systems. Various physico-chemical properties of candidate internal standard materials were correlated with the observed retention times of these compounds. The best correlation (r2 = 0.8077) was obtained between the boiling point and the retention time of the compounds for the current application. The boiling point of an internal standard candidate material may therefore be useful in predicting the retention time of that compound under similar conditions.
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Document Type: Research Article

Affiliations: 1: Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa, Email: olivierei@tut.ac.za 2: Department of Biomedical Sciences, Tshwane University of Technology, Pretoria, South Africa 3: Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, South Africa

Publication date: 2007-10-01

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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