Open Access PAS-FTIR and FT-Raman qualitative characterization of sodium dodecyl sulfate interaction with an alternative stratum corneum model membrane

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The interaction of the surfactant sodium dodecyl sulfate with the stratum corneum (SC) of shed snake skin from Bothrops jararaca, used as a model membrane, was characterized qualitatively by FT-Raman and infrared photoacoustic (PAS-FTIR) spectroscopy, used as analytical tools. Surfactant solutions were 50.0 g · l–1 and 2.34 g · l–1 with treatment intervals of 4, 8 and 12 h. The employment of FT-Raman and PAS-FTIR indicated increased hydration of the SC with alteration of the tissue topography. The interaction of the SC with surfactant was increased by the tape-stripping process. The consequent exposure of the internal layers of the tissue intensified the effect of the anionic surfactant, indicating that this layer acted as an additional barrier.

Document Type: Research Article


Affiliations: 1: Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, FCF-USP, 580 Prof. Lineu Prestes Av., bl. 13/15, Conjunto das Químicas, Cidade Universitária, São Paulo, 05508-900, Brazil, ;, Email: 2: Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil 3: Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil

Publication date: October 1, 2007

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  • Pharmazie is one of the world's leading pharmaceutical journals. As a peer-reviewed scientific journal, DiePharmazie is regularly indexed in Current Contents/Life Sciences, Excerpta Medica, Analytical Abstracts, International Pharmaceutical Abstracts, Beilstein Current Facts in Chemistry, Chemical Engineering and Biotechnology Abstracts (CEABA) and Science Citation Index.
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