Cytotoxicity of different types of methylated β-cyclodextrins and ionic derivatives
Cyclodextrins (CDs) are widely used materials and still in the focus of drug development. In spite of the extensive studies, there is limited information about the cytotoxic effect of different derivatives. This study compares the cytotoxic effect of methylated β-CDs and some ionic
derivatives. The methylated CDs involved in this study differ in the number and position of the methyl substituents. Heptakis(2,6-di-O-methyl)-β-CD (DIMEB) with a degree of substitution (DS) of 14 has two methyl groups in all of the seven glucose subunits mostly at O-2 and O-6
position, each OH group is methylated in heptakis(2,3,6-tri-O-methyl)-β-CD (TRIMEB) (DS = 21), and an unsystematic substitution is realized in randomly methylated β-CD (RAMEB). DS is defined as the number of substituents per cyclodextrin ring.
Using the above definition, the DS for RAMEB is 12.6. To see the effect of the ionic groups an anionic and a cationic CD derivative were also investigated: (2-hydroxy-3-N,N,N-trimethylamino)propyl β-CD (QABCD) (DS = 2) and carboxymethylated β-CD (CMBCD)
(DS = 3,5). The in vitro cell toxicity decreases in the order of DIMEB > TRIMEB ≥ RAMEB > QABCD > CMBCD. Ionic β-CDs were less toxic than the methylated derivatives.
Document Type: Short Communication
Affiliations: 1: Department of Pharmaceutical Technology, University of Debrecen, Debrecen, Hungary 2: Department of Pharmaceutical Technology, University of Debrecen, Egyetem ter 1. P.O. box 78, Debrecen, H-4010, Hungary, Email: [email protected] 3: Cyclolab Ltd., Budapest, Hungary 4: Department of Biophysics and Cell Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
Publication date: 01 July 2007
- Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
- Information for Authors
- Submit a Paper
- Subscribe to this Title
- Ingenta Connect is not responsible for the content or availability of external websites
- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content